Are All Migraines a Genetic Mutation?

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Finally, scientific proof that migraines exist- Migraines are a hereditary, neurological disorder that has been baffling scientists for decades. Now, researchers found a genetic mutation that may explain why certain people suffer from one of the most common types of migraine headaches.

Are All Migraines a Genetic Mutation?

The study on familial migraines provides an important clue to understanding migraines with aura, and why certain people are more likely than others to experience throbbing headaches, nausea, and the characteristic bright, shifting visual auras.

Proving migraines exist

Scientists from UC San Francisco believe they have discovered the first gene of its kind in which mutations directly correlate with migraines with aura; the casein kinase I delta (CKIdelta) gene mutation was present in a significant number of migraine patients…and their parents.

The study, which was published by Science Translational Medicine, “puts us one step closer to understanding the molecular pathway to pain in migraine,” says senior investigator Louis J. Ptácek.

“It’s our initial glimpse into a black box that we don’t yet understand.”

This is the first time researchers have been able to provide both clinical and scientific evidence proving that the casein kinase I delta gene directly causes migraines with aura.

Migraine symptoms

Migraines with aura cause a wide range of symptoms; besides excruciating headaches, other signs of migraine with aura include severe nausea, vomiting, stomach cramps, and eye pain.

Patients also experience hypersensitivity to mild stimuli such as lights, noise, scents, and touch.

To measure migraine symptoms in lab mice, scientists focused on decreased threshold to pain and signs of cortical spreading depression (CSD), a common indicator of migraines with aura that can be observed through medical imaging.

“…as we come to a clearer understanding, we can start thinking about better therapies…There are good drugs now, but they only help some patients, some of the time. The need for better treatments is huge.” – Ptácek

Migraine tips

Your migraine management regimen should include a multi-pronged approach to relieving headaches, preventing migraine triggers, and coping with daily stress.

Even if migraines are hereditary, you can reduce your risks by exercising daily, keeping a migraine diary, learning how to relax, and supplementing with vitamins and minerals that benefit migraine patients, such as riboflavin, CoQ10, butterbur, and magnesium.

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Like this? Read more:

Are Migraines Always Hereditary?

What Causes Migraines? The Long and Short Answers

Is Migraine Disorder a Real Illness?


Genetic Mutation Linked with Typical Form of Migraine

Casein Kinase Iδ Mutations in Familial Migraine and Advanced Sleep Phase

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