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Supplement Facts |
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| Amount per 3 capsules |
| Butterbur Extract |
150 mg (certified free of of Pyrrolizidine Alkaloids (PAs) |
| Proprietary Blend |
876 mg (Riboflavin, Magnesium, Coenzyme Q10 ) | |
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| Butterbur Extract |
(Petasites hybridus) Migravent contains a standardized patented extract of Butterbur that is free of Pyrrolizidine Alkaloids (PAs) and has been used safely for over 25 years in clinical practice. The Butterbur is standardized to contain a minimum of 7.5 mg of petasin and isopetasin. Researchers have found two active compounds in Butterbur- petasin and isopetasin. Together, these substances help reduce spasms in cerebral blood vessels and inhibit the production of leukotriens, compounds that trigger inflammation of blood vessels. Butterbur extract is known to have a spasmolytic effect. This means that it reduces spontaneous activity and spasms in the smooth muscular system, including the vascular walls. Butterbur has long been used for migraine prevention in Europe. A recently published U.S. study demonstrated Butterbur's ability to reduce the frequency of headaches. Researchers at Albert Einstein College of Medicine in New York compared two different doses of butterbur to a placebo among about 230 patients, who had reported two to six migraines per month prior to the study. Results showed that taking 75 milligrams of butterbur twice daily reduced headache frequency by 48 percent.
Results of the new study were published in the Dec. 28, 2004 issue of Neurology. |
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| Riboflavin (Vitamin B2) |
| Vitamin B2 is another preventative ingredient used for Migraines. A study in Belgium found that people who took 400 milligrams of Vitamin B2 daily had about one-third fewer migraines than did those taking a placebo. The study, published in the February issue of the journal Neurology, included 55 patients in Belgium and Luxembourg who normally had two to eight migraine attacks each month. |
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| Magnesium |
| Magnesium deficiency in the brain has been implicated in the pathophysiology of migraines. Magnesium is a mineral that functions as a coenzyme (part of ~100 enzymes) for nerve/muscle function, regulation of body temperature, energy metabolism, DNA/RNA synthesis, and the formation of bones. According to two double-blind studies, high-dose oral magnesium supplementation appears to be effective in migraine prophylaxis. |
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| Coenzyme Q10 |
Coenzyme Q10 has been proven in recent clinical studies to be most effective in preventing migraines. CoenzymeQ10, also known as ubiquinone and found in every cell in the body, is a major mechanism for producing energy. Clinical research has found that migraine sufferers have impaired mitochondrial function resulting in a reduction in energy production. Studies have further proven that CoQ10 enhances this function, thereby causing an anti-migraine effect. In fact, in a clinical study conducted in March 2002 at the Jefferson Headache Center at Thomas Jefferson University in Philadelphia, Pennsylvania thirty-two patients (26 women, 6 men) with a history of episodic migraine with or without aura were treated with Coenzyme Q10 at a dose of 150 mg per day. 61.3% of patients had a greater than 50% reduction in number of days with migraine headache. Also of importance, there were no side effects noted with Coenzyme Q10.
The reported side effects of Migravent are minimal.
There are no known drug interactions with Migravent.
Migravent may be taken along with other prescription medications.
Migravent should be used in caution with people who are taking antibiotics (especially tetracyclines), magnesium containing preparations (such as enemas), sodium polysterene sulfonate, certain chemotherapy drugs, or people with diabetes or heart disease. |
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