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Supplement Facts

PA-Free Butterbur 150 mg
Proprietary Blend 876 mg (Riboflavin, Magnesium, Coenzyme Q10 )  
(Petasites hybridus)
Migravent's PA-Free* Butterbur is tested by a leading independent third party laboratory for the absence of Pyrrolizidine Alkaloids (PAs). (*The laboratory results indicate that "No Pyrrolizidine Alkaloids (PAs) are quantifiable"). The Butterbur is standardized to contain a minimum of 15% of petasin and isopetasin. Researchers have found two active compounds in Butterbur- petasin and isopetasin. Together, these substances help reduce spasms in cerebral blood vessels and inhibit the production of leukotriens, compounds that trigger inflammation of blood vessels. Butterbur extract is known to have a spasmolytic effect. This means that it reduces spontaneous activity and spasms in the smooth muscular system, including the vascular walls. Butterbur has long been used in Europe. A recently published U.S. study demonstrated Butterbur's ability to help support neurological function. Researchers at Albert Einstein College of Medicine in New York compared two different doses of butterbur to a placebo among about 230 patients. The results were very favorable.
Results of the study were published in the Dec. 28, 2004 issue of Neurology.
Vitamin B2 is another important ingredient for migraine sufferers. A study in Belgium found that people who took 400 milligrams of Vitamin B2 daily had favorable outcomes as opposed to placebo. The study, published in the February issue of the journal Neurology included 55 patients in Belgium and Luxembourg.
Magnesium deficiency in the brain has been implicated in the pathophysiology of migraine sufferers. Magnesium is a mineral that functions as a coenzyme (part of ~100 enzymes) for nerve/muscle function, regulation of body temperature, energy metabolism, DNA/RNA synthesis, and the formation of bones. According to two double-blind studies, high-dose oral magnesium supplementation appears to be helpful for migraine sufferers.
Coenzyme Q10 has been proven in recent clinical studies to be most effective in supporting neurological function. CoenzymeQ10, also known as ubiquinone and found in every cell in the body, is a major mechanism for producing energy. Clinical research has found that migraine sufferers have impaired mitochondrial function resulting in a reduction in energy production. Studies have further proven that CoQ10 enhances this function. In fact, in a clinical study conducted in March 2002 at the Jefferson Headache Center at Thomas Jefferson University in Philadelphia, Pennsylvania thirty-two patients (26 women, 6 men) with a history of episodic migraine with or without aura were given Coenzyme Q10 at a dose of 150 mg per day. 61.3% of patients had a significant positive benefit. Also of importance, there were no side effects noted with Coenzyme Q10.

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